The West Indies were all out for 143 against India in the second and final Twenty20 International on Sunday.
West Indies batsmen found the going tough and were bowled out in 19.4 overs.
Mishra, who replaced Stuart Binny, gave away only 24 runs and dismissed three batsmen and made a good impact along with Ashwin (2/11).
Bumrah (2/26) was consistent with his line and length while Mohammed Shami also chipped in with two scalps.
West Indies: 143 all out in 19.4 overs (Johnson Charles 43; Amit Mishra 3/24, R Ashwin 2/11).